国家精神心理疾病临床医学研究中心 办公室副主任 副研究员 硕士生导师

地址：北京市海淀区花园北路51号，邮编：100191

邮箱：changsh@bjmu.edu.cn

电话：010-82805307

教育经历

2009.7~2012.7 中国科学院心理研究所，博士，行为遗传学专业

2004.9~2007.7 中国科学院计算技术研究所，硕士，计算机软件与理论专业，生物信息学方向

2000.9~2004.7 中国民航大学，理学学士，信息与计算科学专业

工作经历

2018.6~今 北京大学第六医院，副研究员

2008.6~2018.6 中国科学院心理研究所，研究实习员，助理研究员，副研究员

2014.5~2015.5 美国北卡罗莱纳大学教堂山分校，遗传和生物统计系，访问学者

2007.10~2008.1 德国吕贝克大学，生物化学研究中心，访问学者

2007.7~2008.5 中国科学院北京基因组研究所，研究实习员

研究兴趣和研究成果

研究兴趣包括：1)利用基因组学和生物信息学技术研究精神疾病的遗传机制;2)遗传、影像、认知等生物医学大数据的信息学整合研究;3)精神疾病的遗传交叉研究;4)基于遗传学及其他多维临床表型数据的疾病风险评估模型研究。

曾入选中国科学院青年创新促进会会员。主持国家自然基金项目2项，国家重点研发计划课题1项，参与973、北京市脑计划等多项课题。担任过国家自然科学基金和英国Wellcome基金评审，10多个杂志的审稿人。主要研究领域是精神疾病的遗传机制研究，迄今在国际主流学术期刊发表了40余篇学术论文，其中21篇为第一/通讯作者，包括Molecular Psychiatry 2篇、Biological Psychiatry 1篇、Nucleic Acids Research 3篇、Neuroscience & Biobehavioral Reviews 1篇，总引用800多次。

代表性论文

(# 并列第一, * 通讯)

1. Jie Sun, Wei Yan, Xing-Nan Zhang, Xiao Lin, Hui Li, Yi-Miao Gong, Xi-Mei Zhu, Yong-Bo Zheng, Xiang-Yang Guo, Yun-Dong Ma, Zeng-Yi Liu, Lin Liu, Jia-Hong Gao, Michael V. Vitiello, Su-Hua Chang*, Xiao-Guang Liu*, Lin Lu*. Polygenic evidence and overlapped brain functional connectivities for the association between chronic pain and sleep disturbance. Translational Psychiatry 2020 Jul 24;10(1):252.

2. Suhua Chang, Li Yang*, Yufeng Wang and Stephen V. Faraone*. Shared Polygenic Risk for ADHD, Executive Dysfunction and Other Psychiatric Disorders. Transl Psychiatry. 2020 Jun 9;10(1):182.

3. Yan Sun#, Suhua Chang#, Zhen Liu, Libo Zhang, Fan Wang, Weihua Yue, Hongqiang Sun, Zhaojun Ni, Xiangwen Chang, Yibin Zhang, Yang Chen, Jiqiang Liu, Lin Lu, Jie Shi*, Identification of novel risk loci with shared effects on alcoholism, heroin and methamphetamine dependence. Molecular Psychiatry 2019 Aug 28

4. Yan Sun#, Suhua Chang#, Fan Wang, Hongqiang Sun, Zhaojun Ni, Weihua Yue, Hang Zhou, Joel Gelernter, Robert T. Malison, Rasmon Kalayasiri, Lin Lu*, Jie Shi*, Genome-wide association study of alcohol dependence in male Han Chinese and cross-ethnic polygenic risk score comparison. Translational Psychiatry 2019 Oct 7;9(1):249..

5. Yang Zhang#, Yan Sun#, Zhoulong Yu, Yankun Sun, Xiangwen Chang, Lin Lu, Suhua Chang*, Jie Shi* Risk factors and an early prediction model for persistent methamphetamine-related psychiatric symptoms. Addiction Biology 2019. doi: 10.1111/adb.12709.

6. Yang, L.#, Chang, S.#, Lu, Q., Zhang, Y., Wu, Z., Sun, X. et al. A new locus regulating MICALL2 expression was identified for association with executive inhibition in children with attention deficit hyperactivity disorder. Mol Psychiatry 2018. 23(4): 1014-1020.

7. Sun X, Wu Z, Cao Q, Qian Y, Liu Y, Yang B, Chang S*, Yang L*, Wang Y. Genetic variant for behavioral regulation factor of executive function and its possible brain mechanism in attention deficit hyperactivity disorder. Scientific reports 2018, 8(1): 7620.

8. Fan ZL#, Qian Y#, Lu Q, Wang YF, Chang SH*, Yang L*. DLGAP1 and NMDA receptor-associated postsynaptic density protein genes influence executive function in attention deficit hyperactivity disorder. Brain and behavior 2018, 8(2).

9. Zhang, K.,#, Qu, S.#, Chang, S.#, Li, G., Cao, C., Olff, M., et al. (2017) An overview of posttraumatic stress disorder genetic studies by integrating and analyzing genetic data into genetic database PTSDgene. Neuroscience and Biobehavioral Reviews. 83: 647-656.

10. Zhang K#, Fan Z#, Wang Y, Faraone SV, Yang L*, Chang S*. Genetic analysis for cognitive flexibility in the trail-making test in attention deficit hyperactivity disorder patients from single nucleotide polymorphism, gene to pathway level. The World Journal of Biological Psychiatry 2017: 1-10.

11. Wang, J., Qu, S., Wang, W., Guo, L., Zhang, K., Chang, S.* and Wang, J.* (2016). A combined analysis of genome-wide expression profiling of bipolar disorder in human prefrontal cortex. J Psychiatr Res 82: 23-29.

12. Chang, S.#, Fang, K.#, Zhang, K., and Wang, J.*, (2015) Network-Based Analysis of Schizophrenia Genome-Wide Association Data to Detect the Joint Functional Association Signals, PLoS One, 10, e0133404.

13. Chang, S.#, Wang, J.#, Zhang, K., and Wang, J.*, (2015) Pathway-Based Analysis for Genome-Wide Association Study Data of Bipolar Disorder Provides New Insights for Genetic Study, Protein Cell, 6, 912-5.

14. Zhang, K.#, Chang, S.#, Guo, L., Wang, J.* (2014) I-GSEA4GWAS v2: a web server for functional analysis of SNPs in trait-associated pathways identified from genome-wide association study. Protein & Cell, 6, 221-224.

15. Chang, S.#, Gao, L.#, Li, Z.#, Zhang, W.#, Du, Y., & Wang, J.* (2013) BDgene: A Genetic Database for Bipolar Disorder and Its Overlap With Schizophrenia and Major Depressive Disorder. Biol Psychiatry, doi: 10.1016/j.biopsych.2013.04.016

16. Chang, S., Zhang, W., Gao, L., & Wang, J.* (2012) Prioritization of candidate genes for attention deficit hyperactivity disorder by computational analysis of multiple data sources. Protein Cell, 3(7), 526-534. doi: 10.1007/s13238-012-2931-7

17. Zhang, L.#, Chang, S.#, Li, Z., Zhang, K., Du, Y., Ott, J., et al. (2012) ADHDgene: a genetic database for attention deficit hyperactivity disorder. Nucleic Acids Res, 40(Database issue), D1003-1009. doi: 10.1093/nar/gkr992